Enhanced Hemocompatibility of Lysine Grafted Polyacrylonitrile Electrospun Nanofiber Membranes as a Potential Bilirubin Adsorption in Hemoperfusion

Hyperbilirubinemia is one of most severe clinical diseases, which caused by the accumulation unconjugated bilirubin. Electrospun nanofiber membranes used as highly efficient bilirubin adsorbents have been applied to remove extra in hemoperfusion for their high surface area and easy functionalized properties. In this work, Lysine (Lys) grafted polyacrylonitrile (PAN) electrospun doped with organic Hectorite (OHec) (Lys-HPAN@OHec) fabricated via a series modified process, including pore forming, alkaline hydrolysis grafting reaction. The obtained Lys-HPAN@OHec analyzed detail investigated adsorption capacity Compared original PNA membranes, show an excellent more stable rejection rate bovine serum albumin (BSA). maximum 64 mg/g, process matched Langmuir model well. addition, dynamic reveals that equilibrium time about 2 h. Significantly, biocompatibility hemocompatibility. This study demonstrates novel may provide new way treat hyperbilirubinemia.